| Home | Score | Away | League | Time (CST) |
|---|---|---|---|---|
| Universidad Católica del Ecuador | 0:0 | LDU Quito | Ecuadorian Serie A | 06:00 |
| One Knoxville | 0:0 | Fort Wayne FC | American USL League One | 06:30 |
| Real Potosí | 1:0 | San Antonio Bulo Bulo | Bolivian Primera División | 06:00 |
| Leones | 1:1 | Deportivo Cuenca | Ecuadorian Serie A | 06:00 |